The success of drug treatment in humans depends on two groups of factors: genetic and non-genetic. Non-genetic is the diagnosis, gender, age, lifestyle, diet, bad habits, and many others. Genetic ones are features of your genetic code that determine the body's response to medications. Together, they determine the body's response to the drug: effectiveness, inefficiency, and undesirable drug reactions.
In some cases, by analyzing the genetic characteristics of a particular patient through pharmacogenetic testing, it is possible to predict the effect of the drug before it is prescribed. This allows, firstly, to immediately exclude the prescription of wrong drugs, and secondly, to choose the most correct dosage of appropriate ones, thus avoiding undesirable drug reactions that can occur in the range of severity from mild to fatal.
Pharmacogenetic testing is the identification of specific features in specific genes that determine the work of a drug when it is used in a patient.
Pharmacogenetic testing is recommended for people with a high risk of adverse drug reactions and patients with a history of heredity.
To date, many large pharmacogenetic studies have been conducted to study the sensitivity of patients with different genetic characteristics to specific drugs. Two international organizations, CPIC and DPWG, accumulate all the scientific knowledge that appears in medicine in different nosologies.
For example, there is evidence of the importance of preliminary pharmacogenetic testing in cardiology, oncology, psychiatry, neurology, gastroenterology, endocrinology, dermatology, and others.
The recommendations based on the results of pharmacogenetic testing will not contain data on the use of common over-the-counter medications, such as activated charcoal or paracetamol. Recommendations contain information about prescription medications prescribed by a doctor for serious diseases. For example, pharmacogenetics is critical when prescribing anticoagulants or antidepressants.
After submitting the biomaterials to the laboratory and conducting their research, you will receive a PDF report containing information about your genetic profile, indicating the features of metabolism, as well as personalized information about the use of 650 drugs in 52 drug groups for 9 nosologies:
Recommendations based on the results of the study are relevant to you throughout your life, provided that you do not use DNA editing technology. Save the report and show it to your doctors when treating various diseases that occur in the future.
For pharmacogenetic analysis, the laboratory will study only specific DNA areas involved in the work of drugs: cytochrome P-450 isoenzymes (CYP2D6, CYP2C9, CYP2C19, etc.), biotransformation phase II enzymes (N-acetyltransferase, glutathione-S-transferase), drug transporters (P-glycoprotein, organic anion, cation transporters). This allows you to reduce the cost and time of research and make it as affordable as possible, both financially and in terms of time to get results. This is why PGX2 collaborates with laboratories that can provide results cheaply and quickly for pharmacogenetic analysis by performing them using PCR (Real-time PCR and PCR RFLP), and not just using next-generation sequencing (NGS) data, which is much more expensive and has a long execution time.
General genetic tests available on the market today include a significantly smaller number of drugs (maximum 130 vs. 650 PGX2), and the duration of the study takes longer (30-40 days vs. 2-3 days in PGX2 partner laboratories).
Yes, if you have done a genetic study using next-generation sequencing (NGS) and have raw data in VCF format, we can decode the data and form pharmacogenetic recommendations based on it. For more details, you can contact us by this email address email@example.com
To do a pharmacogenetic test, contact one of our partner laboratories. After submitting the biological material (saliva) to the laboratory and its analysis, which takes several days, the results will be sent to your email in the form of a PDF report. In some laboratories, the report is also available in your personal account.
If you have not received answers to your questions, you can make an appointment for a consultation with a pharmacogeneticist by writing to us at firstname.lastname@example.org